Use an opcode cache like APC, setup w3-total-cache plugin too.

The last WP blog I setup used the following:
- PHP5 w/APC
- w3-total-cache
- nginx web server (using try_files to handle rewrites)

Usually that's enough for most blogs and will help a lot with speed.
JmZ Reviewed by JmZ on . Optimizing Speed What's a good wordpress plugin, that will optimize the speed of the site? Rating: 5