This is how I do it ....

In this example, Godaddy is the registrar.

1) Add a host for ns1 and ns2 with the IP(s) provided.
2) Then make the nameservers ns1.yourdomain.com / ns2.yourdomain.com

Then go into kloxo:

1) Make a new DNS template
2) Fill in the ns1.your domain.com / ns2.yourdomain

Then

1) Add a domain and use the template you created.

Wait until it has propagated and then http://yourdomain.com, the kloxo default page shows up.